Univ. Prof. Dr. med. Simone Marnitz

Head Dpt. Radiation Oncology, CyberKnife Center
University Clinic Cologne
Reference Site Radiation Therapy (German Hodgkin
Lymphoma Group, GHSG)
Kerpener Str. 62
50937 Cologne, Germany
Tel. +49 221 478 84763
simone.marnitz-schulze@uk-koeln.de

1. EDUCATION AND ACADEMIC CARREER

08/1989 University Entrance Diploma, Berlin, Germany
1989-1991 Nursing stuff at a specialized hospital for mentally and
physically disabled children, Berlin, Germany
09/1991 - 08/1997 Medical studies, Charité Medical Faculty, Humboldt-
University , Berlin, Germany; Medical Degree
03/1995 – 10/1997 Thesis: Tumor-scintigraphy in breast cancer patients:
Analysis of validity, accuracy and toxicity (Prof.I.Reisinger,
Charité)
11/1997 – 12/2001 Internship and residency Radiation Oncology Charité,
Berlin, Prof. V. Budach
01/2002-04/2003 Residency Radiation Oncology, University Clinic Essen,
Prof. M. Stuschke
01/2003 Board Certification Radiation Oncology, Ärztekammer
Nordrhein, Düsseldorf
2003-2005 Senior physician for proton therapy Hahn-Meitner-Institut,
Berlin
2006-2015 Vice Head Department for Radiation Oncology, Charité,
Berlin
07/2007 Postdoctoral lecture qualification (Radiation Oncology)
01/2011 Appointment Ass. Professorship (Radiation Oncology),
Charité University Medicine
10/2015 Appointment Professorship, Head of the Department for
Radiation Oncology, University Cologne
01/2016 Appointment Professorship, Head of the Department for
Radiation Oncology, University Jena (rejected).

2. MEMBERSHIP

  ASTRO, ESTRO, DEGRO, ARO, DGGG, AGO

3. FUNCTIONS

11/2006 - present Member National Guideline Committee for the Cervical Cancer
2015-present Member National Guideline Committee for the Treatment of Vaginal
and Vulvar Cancer.
Member National Guideline Committee for Fertility Preservation

4. CLINICAL STUDIES (IIT WITH GRANTS AND PI)

2009 - present Role: Principal Investigator
Role of Surgical Versus Clinical Staging in Chemoradiated FIGO
Stage IIB-IVA Cervical Cancer Patients-Acute Toxicity and
Treatment Quality of the Uterus-11 Multicenter Phase III Intergroup
Trial of the German Radiation Oncology Group and the
Gynecologic Cancer Group.
2009-2013 n=255 enrolled patients, results in press and published,
funded by Deutsche Krebshilfe (German Cancer Organization)
2016 Role: Principal Investigator
Neoadjuvant chemotherapy followed by radical hysterectomy
versus primary chemo-radiation in patients with FIGO IB2 and IIB
cervical cancer.
Funded by Deutsche Krebshilfe (German Cancer Organization).
Start of recruitment 2018

5. PUBLICATIONS

  1. Köhler C, Marnitz S. Cancer in pregnancy: evidence, or still empiricism?
    Lancet Oncol. 2018 ;19(3):272-274.2. Temming S, Kocher M, Stoelben E, Hag
  2. meyer L, Chang DH, Frank K, Hekmat
    K, Wolf J, Baus WW, Semrau R, et al: Risk-adapted robotic stereotactic
    body radiation therapy for inoperable early-stage non-small-cell lung
    cancer. Strahlenther Onkol 2018, 194:91-97.
  3. Meyer MF, Meinrath J, Seehawer J, Lechner A, Odenthal M, Quaas A,
    Semrau R, Huebbers CU, Marnitz S, Buttner R, Beutner D: The relevance of
    the lymph node ratio as predictor of prognosis is higher in HPV-negative
    than in HPV-positive oropharyngeal squamous cell carcinoma. Clinical
    Otolaryngology 2018, 43:192-198.
  4. Kohler C, Marnitz S: Cancer in pregnancy: evidence, or still empiricism?
    Lancet Oncol 2018.
  5. Tsunoda AT, Marnitz S, Soares Nunes J, Mattos de Cunha Andrade CE,
    Scapulatempo Neto C, Blohmer JU, Herrmann J, Kerr LM, Martus P,
    Schneider A, et al: Incidence of Histologically Proven Pelvic and Para-
    Aortic Lymph Node Metastases and Rate of Upstaging in Patients with
    Locally Advanced Cervical Cancer: Results of a Prospective Randomized
    Trial. Oncology 2017, 92:213-220.
  6. Mor JM, Semrau R, Baus W, Koch KR, Schaub F, Cursiefen C, Marnitz S,
    Heindl LM: [CyberKnife(R): new treatment option for uveal melanoma].
    Ophthalmologe 2017.
  7. Marnitz S: [Substantial advantage of CT-planned HDR brachytherapy for
    cervical cancer patients compared to a historical series with regard to
    local control and toxicity?]. Strahlenther Onkol 2017, 193:236-239.
  8. Kriz J, Baues C, Engenhart-Cabillic R, Haverkamp U, Herfarth K, Lukas P,
    Schmidberger H, Marnitz-Schulze S, Fuchs M, Engert A, Eich HT: New
    quality assurance program integrating "modern radiotherapy" within the
    German Hodgkin Study Group. Strahlenther Onkol 2017, 193:100-108.
  9. Celik E, Semrau R, Baues C, Trommer-Nestler M, Baus W, Marnitz S: Robotassisted
    Extracranial Stereotactic Radiotherapy of Adrenal Metastases in
    Oligometastatic Non-small Cell Lung Cancer. Anticancer Res 2017,
    37:5285-5291.
  10. Baues C, Trommer-Nestler M, Jablonska K, Brockelmann PJ, Schlaak M, von
    Bergwelt-Baildon M, Engert A, Semrau R, Marnitz S, Theurich S: Short
    review of potential synergies of immune checkpoint inhibition and
    radiotherapy with a focus on Hodgkin lymphoma: radio-immunotherapy
    opens new doors. Immunotherapy 2017, 9:423-433.
  11. Baues C, Semrau R, Gaipl US, Brockelmann PJ, Rosenbrock J, Engert A,
    Marnitz S: Checkpoint inhibitors and radiation treatment in Hodgkin's
    lymphoma : New study concepts of the German Hodgkin Study Group.
    Strahlenther Onkol 2017, 193:95-99.
  12. Stromberger C, Cozzi L, Budach V, Fogliata A, Ghadjar P, Wlodarczyk W,
    Jamil B, Raguse JD, Bottcher A, Marnitz S: Unilateral and bilateral neck SIB
    for head and neck cancer patients : Intensity-modula ted proton therapy,
    tomotherapy, and RapidArc. Strahlenther Onkol 2016.
  13. Schnurch HG, Ackermann S, Alt CD, Barinoff J, Boing C, Dannecker C,
    Gieseking F, Gunthert A, Hantschmann P, Horn LC, et al: Diagnosis,
    Therapy and Follow-up Care of Vulvar Cancer and its Precursors.
    Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number
    015/059, November 2015. Geburtshilfe Frauenheilkd 2016, 76:1035-1049.
  14. Marnitz S, Martus P, Kohler C, Stromberger C, Asse E, Mallmann P,
    Schmidberger H, Affonso Junior RJ, Nunes JS, Sehouli J, Budach V: Role of
    Surgical Versus Clinical Staging in Chemoradiated FIGO Stage IIB-IVA
    Cervical Cancer Patients-Acute Toxicity and Treatment Quality of the
    Uterus-11 Multicenter Phase III Intergroup Trial of the German Radiation
    Oncology Group and the Gynecologic Cancer Group. Int J Radiat Oncol
    Biol Phys 2016, 94:243-253.
  15. Kohler C, Marnitz S, Biel P, Cordes T: Successful Delivery in a 39-Year-Old
    Patient with Anal Cancer after Fertility-Preserving Surgery Followed by
    Primary Chemoradiation and Low Anti-Mullerian Hormone Level.
    Oncology 2016.
  16. Kohler C, Le X, Dogan NU, Pfiffer T, Schneider A, Marnitz S, Bertolini J,
    Favero G: Molecular diagnosis for nodal metastasis in endoscopically
    managed cervical cancer: the accuracy of APTIMA(R) test to detect high
    risk HPV-mRNA in sentinel lymph nodes. J Minim Invasive Gynecol 2016.
  17. Kohler C, Foiato T, Marnitz S, Schneider A, Le X, Dogan NU, Pfiffer T, Jacob
    AE, Molgg A, Hagemann I, Favero G: Potential Surgical and Oncologic
    Consequences Related to Skin Tattoos in the Treatment of Cervical
    Cancer. J Minim Invasive Gynecol 2016, 23:1083-1087.
  18. Dessole M, Petrillo M, Lucidi A, Naldini A, Rossi M, De Iaco P, Marnitz S,
    Sehouli J, Scambia G, Chiantera V: Quality of Life in Women After Pelvic
    Exenteration for Gynecological Malignancies: A Multicentric Study. Int J
    Gynecol Cancer 2016.
  19. Baues C, Semrau R, Gaipl US, Brockelmann PJ, Rosenbrock J, Engert A,
    Marnitz S: Checkpoint inhibitors and radiation treatment in Hodgkin's
    lymphoma : New study concepts of the German Ho dgkin Study Group.
    Strahlenther Onkol 2016.
  20. Stromberger C, Wlodarczyk W, Marnitz S, Jamil B, Budach V, Raguse JD,
    Boettcher A, Badakhshi H: Simultaneous Integrated Boost (SIB): RapidArc
    and Tomotherapy Plan Comparison for Unilateral and Bilateral Neck
    Irradiation. Anticancer Res 2015, 35:2991-2997.
  21. Stromberger C, Ghadjar P, Marnitz S, Thieme AH, Jahn U, Raguse JD, Karaj-
    Rossbacher E, Bottcher A, Jamil B, Budach V: Comparative treatment
    planning study on sequential vs. simultaneous integrated boost in head
    and neck cancer patients : Differences in dose distributions and
    potential implications for clinical practice. Strahlenther Onkol 2015.
  22. Poortmans PM, Collette S, Kirkove C, Van Limbergen E, Budach V,
    Struikmans H, Collette L, Fourquet A, Maingon P, Valli M, et al: Internal
    Mammary and Medial Supraclavicular Irradiation in Breast Cancer. N Engl
    J Med 2015, 373:317-327.
  23. Marnitz S, Wlodarczyk W, Neumann O, Koehler C, Weihrauch M, Budach V,
    Cozzi L: Which technique for radiation is most beneficial for patients with
    locally advanced cervical cancer? Intensity modulated proton therapy
    versus intensity modulated photon treatment, helical tomotherapy and
    volumetric arc therapy for primary radiation - an intraindividual
    comparison. Radiat Oncol 2015, 10:91.
  24. Marnitz S, Schram J, Budach V, Sackerer I, Vercellino GF, Sehouli J, Kohler
    C: Extended field chemoradiation for cervical cancer patients with
    histologically proven para-aortic lymph node metastases after
    laparaoscopic lymphadenectomy. Strahlenther Onkol 2015, 191:421-428.
  25. Marnitz S, Abt EC, Martus P, Tsunoda A, Kohler C: Is Routine Curettage a
    Useful Tool to Evaluate Persistent Tumor in Patients Who Underwent
    Primary Chemoradiation for Locally Advanced and/or Lymph Node
    Positive Cervical Cancer? Int J Gynecol Cancer 2015.
  26. Kohler C, Oppelt P, Favero G, Morgenstern B, Runnebaum I, Tsunoda A,
    Schmittel A, Schneider A, Mueller M, Marnitz S: How much platinum passes
    the placental barrier? Analysis of platinum applications in 21 patients
    with cervical cancer during pregnancy. American Jou rnal of Obstetrics and
    Gynecology 2015, 213.
  27. Kohler C, Mustea A, Marnitz S, Schneider A, Chiantera V, Ulrich U, Scharf JP,
    Martus P, Vieira MA, Tsunoda A: Perioperative morbidity and rate of
    upstaging after laparoscopic staging for patients with locally advanced
    cervical cancer: results of a prospective randomized trial. Am J Obstet
    Gynecol 2015, 213:503 e501-507.
  28. Kohler C, Kyeyamwa S, Marnitz S, Tsunoda A, Vercelino F, Schneider A,
    Favero G: Prevention of lymphoceles using FloSeal and CoSeal after
    laparoscopic lymphadenectomy in patients with gynecologic
    malignancies. J Minim Invasive Gynecol 2015, 22:451-455.
  29. Horn LC, Beckmann MW, Follmann M, Koch MC, Mallmann P, Marnitz S,
    Schmidt D: [S3 guidelines on diagnostics and treatment of cervical
    cancer: Demands on pathology]. Pathologe 2015, 36:585-593.
  30. Ghadjar P, Budach V, Kohler C, Jantke A, Marnitz S: Modern radiation
    therapy and potential fertility preservation strategies in patients with
    cervical cancer undergoing chemoradiation. Radiat Oncol 2015, 10:50.
  31. Budach V, Stromberger C, Poettgen C, Baumann M, Budach W, Grabenbauer
    G, Marnitz S, Olze H, Wernecke KD, Ghadjar P: Hyperfractionated
    accelerated radiation therapy (HART) of 70.6 Gy with concurrent 5-
    FU/Mitomycin C is superior to HART of 77.6 Gy alone in locally advanced
    head and neck cancer: long-term results of the ARO 95-06 randomized
    phase III trial. Int J Radiat Oncol Biol Phys 2015, 91:916-924.
  32. Stromberger C, Jann D, Becker ET, Raguse JD, Tinhofer I, Marnitz S, Budach
    V: Adjuvant simultaneous integrated boost IMRT for patients with
    intermediate- and high-risk head and neck cancer: outcome, toxicities
    and patterns of failure. Oral Oncol 2014, 50:1114-1121.
  33. Neumann O, Kluge A, Lyubina O, Wlodarczyk W, Jahn U, Kohler C, Budach
    V, Kufeld M, Marnitz S: Robotic radiosurgery as an alternative to
    brachytherapy for cervical cancer patients. Strahlenther Onkol 2014,
    190:538-545.
  34. Muallem MZ, Marnitz S, Richter R, Kohler C, Sehouli J , Arsenic R: ERCC1
    expression as a predictive marker of cervical cancer treated with
    cisplatin-based chemoradiation. Anticancer Res 2014, 34:401-406.
  35. Marnitz S, Zich A, Martus P, Budach V, Jahn U, Neumann O, Arnold R: Longterm
    results of total body irradiation in adults with acute lymphoblastic
    leukemia. Strahlenther Onkol 2014, 190:453-458.
  36. Marnitz S, Kohler C, Rauer A, Schneider A, Budach V, Tsunoda A, Mangler M:
    Patterns of care in patients with cervical cancer 2012: results of a survey
    among German radiotherapy departments and out-patient health care
    centers. Strahlenther Onkol 2014, 190:34-40.
  37. Chiantera V, Rossi M, De Iaco P, Koehler C, Marnitz S, Gallotta V, Margariti
    AP, Parazzini F, Scambia G, Schneider A, Vercellino GF: Pelvic exenteration
    for recurrent endometrial adenocarcinoma: a retrospective multiinstitutional
    study about 21 patients. Int J Gynecol Cancer 2014, 24:880-
    884.
  38. Chiantera V, Rossi M, De Iaco P, Koehler C, Marnitz S, Ferrandina G, Legge
    F, Parazzini F, Scambia G, Schneider A, Vercellino GF: Survival after
    curative pelvic exenteration for primary or recurrent cervical cancer: a
    retrospective multicentric study of 167 patients. Int J Gynecol Cancer
    2014, 24:916-922.
  39. Chiantera V, Rossi M, De Iaco P, Koehler C, Marnitz S, Fagotti A, Fanfani F,
    Parazzini F, Schiavina R, Scambia G, et al: Morbidity after pelvic
    exenteration for gynecological malignancies: a retrospective multicentric
    study of 230 patients. Int J Gynecol Cancer 2014, 24:156-164.
  40. Stromberger C, Gruen A, Wlodarczyk W, Budach V, Koehler C, Marnitz S:
    Optimizing image guidance frequency and implications on margins for
    gynecologic malignancies. Radiat Oncol 2013, 8:110.
  41. Marnitz S, Kohler C, Budach V, Neumann O, Kluge A, Wlodarczyk W, Jahn U,
    Gebauer B, Kufeld M: Brachytherapy-emulating robotic radiosurgery in
    patients with cervical carcinoma. Radiat Oncol 2013, 8:109.
  42. Mangler M, Zech N, Schneider A, Kohler C, Marnitz S: Aspects of Therapy
    for Cervical Cancer in Germany 2012 - Results from a Survey of German
    Gynaecological Hospitals. Geburtshilfe Frauenheilkd 2013, 73:227-238.
  43. Gruen A, Ebell W, Wlodarczyk W, Neumann O, Kueh l JS, Stromberger C,
    Budach V, Marnitz S: Total Body Irradiation (TBI) using Helical
    Tomotherapy in children and young adults undergoing stem cell
    transplantation. Radiat Oncol 2013, 8:92.
  44. Clivio A, Kluge A, Cozzi L, Kohler C, Neumann O, Vanetti E, Wlodarczyk W,
    Marnitz S: Intensity modulated proton beam radiation for brachytherapy
    in patients with cervical carcinoma. Int J Radiat Oncol Biol Phys 2013,
    87:897-903.